In 2005 Huffman played Bree, a pre-operative transsexual who, on the brink of her transforming surgery, discovered that in her youth she had fathered a son - who is now a troubled teen hustler on the run, in independent drama Transamerica.
Huffman's performance in the film Transamerica was praised by many critics and garnered her a Golden Globe Award for Best Actress as well as nominations for Best Actress (Screen Actors Guild) and Best Actress (Academy Awards) and several another awards and nominations.
Felicity Kendall Huffman (born December 9, 1962) is an American film, stage, and television actress.
She is known for her role as executive producer Dana Whitaker on the ABC television show Sports Night (1998–2000), which earned her a Golden Globe Award nomination.
After a recurring role on the NBC sitcom Frasier, Huffman landed a leading role in an ABC comedy series "Desperate Housewives", co-starring with Marcia Cross, Teri Hatcher, Nicollette Sheridan and Eva Longoria.
Huffman won an Emmy Award for her work on "Desperate Housewives" (Outstanding Lead Actress in a Comedy Series) in 2005, as well as two 2006 Screen Actors Guild Awards (Best Actress - Comedy Series and part of Best Ensemble - Comedy Series) in 2006 and received several other awards.
She was born in Bedford, New York, the daughter of Grace Valle (née Ewing), an actress, and Moore Peters Huffman, a banker and partner at Morgan Stanley.
Her parents divorced a year after her birth, and she was raised mostly by her mother.
In 1995, Huffman won Obie Award for her performance in the critically successful play The Cryptogram by David Mamet.In 1999 she appeared in the Paul Thomas Anderson's ensemble drama Magnolia and television adaptation of 1938 movie A Slight Case of Murder along with William H. In 2002 she played Lady Bird Johnson in HBO award-winning movie Path to War and made a cameo appearance in the Door to Door, where was shot her husband.She also starred in Snap Decision (2001) with Mare Winningham, Raising Helen (2004) as Kate Hudson's older sister, and Christmas with the Kranks (2004) as Jamie Lee Curtis's best friend.A report in November 2010 suggested that Huffman, along with co-star Teri Hatcher, would be quitting "Desperate Housewives". The series ended in May 2012 after a total of eight seasons. Macy, with whom she has two daughters, Sophia Grace (born August 1, 2000) and Georgia Grace (born March 14, 2002). She has appeared on television, in movies, and on stage many times with her husband.In 2005, Huffman revealed that she had suffered from both anorexia and bulimia in her late teens and twenties.