Are all H1 antagonists innately sedating or is it just the first generation ones?
Anyway I'd like to know which of them (regardless as their branding as 'antihistamines') has the strongest affiliations with these receptors known for producing hypnotic properties.
Sure, they may all antagonize H1, but antagonization of H1 is not the only thing that produces sedation!
In general, PA requests submitted for a non-preferred generic drug must meet the criteria for the drug itself and the prescriber must provide medical records documenting an inadequate response or adverse reaction to the respective preferred brand name drug.
Combinations of antihistamines and decongestants (for example, chlorpheniramine/pseudoephedrine) may be payable under Mass Health, but may not be listed in the antihistamine table. This designates a brand-name drug with FDA “A”-rated generic equivalents.
From what I can tell I think the list beginning with the strongest goes something like this: Quetiapine (seroquel) Mirtazipine (remeron) (from experience) Hydrazine Promethazine (from inference from the internet's experience) --------- Anything else I'm missing here?
--------- IMHO dipenhydramine, trazadone and haldol are not even worthy of placing on this list, unless you like restless leg syndrome and feeling like a mental ward patient.